With average Ø244. 5 mm casing setting depth of 5 045 m in Panyu oilfield extended reach wells(ERWs) , which have features such as long open hole with high hold inclination, high friction factor in open hole with multi-interbed, narrow safety window of drilling fluid density in fault location which tend to cause fracture downhole loss in 244. 5 mm casing running process. Currently, casing floatation collar technology was chiefly used in ERWs, which may have disadvantage risks such as floatation collar failure, limited measurements to deal with casing stuck and so on. In light of reality such as shallow true vertical depth(TVD) and long extended hole section in Panyu oilfield ERWs, a rotating casing running technology with full-floatation was presented to avoid those risks. In this paper, technical principle was analyzed and key technologies such as over drive system, stress check of casing string and the selection of casing flotation package were introduced entirely. The effects of this technique were elaborated. Through 6 of Ø244. 5 mm extended-reach wells applications, the results show that, during the rotating running of casing with full-floatation, decrease casing string load, increase hook load safety factor, run casing string through tight section smoothly and get through fault safely without downhole loss, differential stuck and other downhole complications. All ERWs′ Ø244. 5 mm casing string were set at designed depth.